精神病院的默奇逊院长即将退休,接手的是年轻有为的爱德华大夫(格利高里·派克 Gregory Peck 饰)。医院里年轻漂亮的女医生彼特森(英格丽·褒曼 Ingrid Bergman 饰)和他相爱,然而竟发现眼前的爱人不是爱德华大夫,而真实的爱德华的秘书,还前来指出这个冒牌人士是杀害爱德华的凶手。 面对恋人扑朔迷离的身份,彼特森始终不相信他是杀人凶手,然而默奇逊院长却用精神分析法印证了“事实”。更为棘手的是,这个假爱德华也相信自己有罪,他甚至连自己是谁,经历过的事情也不知道。 彼特森对自己的判断非常坚持,她决定要帮他找出事件真相。在警察的追捕下,她带他逃到了心理分析教授的家中,展开了一联串精彩的心理分析过程,他童年的阴影和爱德华大夫被杀的真相渐渐浮出水面。The head of the Green Manors mental asylum Dr. Murchison is retiring to be replaced by Dr. Edwardes, a famous psychiatrist. Edwardes arrives and is immediately attracted to the beautiful but cold Dr. Constance Petersen. However, it soon becomes apparent that Dr. Edwardes is in fact a paranoid amnesiac impostor. He goes on the run with Constance who tries to help his condition and solve the mystery of what happened to the real Dr. Edwardes.