盧比歐為凶狠的墨西哥販毒團體走私槍械，美國ATF幹員漢克試圖逮捕違法的盧比歐反被對方綁架，盧比歐決定將漢克帶回墨西哥交給老闆決定生死，但在這六百英里的長途旅行中，兩人逐漸成為朋友。Arnulfo Rubio smuggles weapons for a deadly Mexican cartel. ATF agent Hank Harris attempts to apprehend him, but gets kidnapped by Rubio, instead. Rubio takes him to his bosses, but during the 600-miles-long drive, they slowly befriend.
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